Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology. Plaquenil and weight loss surgery Plaquenil poisoning Malaria chloroquine resistant areas Residul plaquenil in the eye Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking hydroxychloroquine and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. Call your doctor at once if you have The damage to the retina can lead to visual field defects, decreased visual acuity, colour-vision defects, and abnormalities in ERG and EOG. 109 – 111 There are many factors that may contribute to hydroxychloroquine retinopathy. These factors include daily and cumulative dosage, duration of treatment, renal or liver disease, patient’s age. Ophthalmological ReactionsCardiomyopathy and Qt ProlongationHaematological ReactionsNeurological and Neuromuscular Reactions While early toxicity may be asymtomatic, patients with more advanced stage of toxicity may complain of color vision changes or paracentral scotomas. Its toxic effects on the retina are seen in the macula. Hydroxychloroquine and nerve damage Hydroxychloroquine Oral Route Side Effects - Mayo Clinic, Ocular side effects of anti-rheumatic medications what a. What tyoe of arthritis is plaquenil He told me to stop the Plaquenil because sometimes it can cause nerve damage. He told me to stop it for two weeks and come back in. He said nerve damage is a side effect. Although it is rare he has seen it happen. I was wondering if anyone else has had this happen and if the damage reversed once it was discontinued. Thanks for your repies. Plaquenil and nerve damage - Scleroderma - Inspire. Risks of Hydroxychloroquine. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria. For information and support call 0300 3030 111. Hydroxychloroquine is a medication used to treat several conditions including rheumatoid arthritis, systemic lupus erythematosus, some skin conditions especially photosensitive ones and others that involve inflammation. Doctors probably assumed that the nerve issues were due to the lupus in those patients. Plaquenil was never really a popular treatment. It does cause damage to the nerves in the retina for some people too.is probably an effect that was just very noticeable at first and the other nerve damage was less visible. I also had elevated CK indicative of muscle damage, and EMG showed chronic nerve damage. I started on plaquenil 3 months after that, and I took it for 3 1/2 years. Never noticed any difference on or off.