I had some of the usual problems with the upset stomach at the beginning but it got better with time. Over the last 8-10 weeks I have noticed that I have been getting very dark circles under my eyes which starts at the inner corner of my eye. Drug quinine and chloroquine Mechanism of action hydroxychloroquine Plaquenil brand name cost Plaquenil screening optometry The pathogenesis underlying drug-related dyspigmentation can also be categorized into 3 mechanisms, which are 1 drug or drug metabolite deposition in the dermis and epidermis, 2 enhanced melanin production with or without an increase in the number of active melanocytes, and 3 drug-induced postinflammatory changes to skin. Nonmelanic pigmentation occurs when the nail matrix extracts the drug and stores it in the nail, or the drug deposits in the nail or subungual area. The nail may turn blue, brown, or gray, depending on the drug, and the color will grow out as the nail does. 1,20,21; Irritant or allergic reactions. Topical agents sometimes cause nail changes. The nail color of fingernails and toenails can reveal certain serious health conditions for instance white nails may be indicative of kidney or liver disorders or anemia. Key Points Healthy fingernails and toenails should be white as it grows off the nail bed and the nail plate a pinkish color. I thought it was because I was not doing very well for a couple of weeks.... When I looked closer the skin is a little red with a bluish black color like a bruise. Gray nails and plaquenil Common and Rare Side Effects for Plaquenil Oral, Drug-Induced Nail Changes Counting to 10 How long for plaquenil to start workingChloroquine cdc malaria Skin pigmentation related to use of hydroxychloroquine starts out as a yellow brown to slate gray or black pigmentation on many areas of the body - especially the front of the shins but also the face, forearms, mouth mucosa essentially hard palace and gingivae and nail beds. How common is it? Skin Pigmentation with Hydroxychloroquine Plaquenil.. Color of Fingernails and Toenails Health Indicator Chart.. Erythema Dyschromicum PerstansAshy Dermatosis- Causes.. Show off an exciting and new signature nail polish color from OPI. Browse OPI nail polish colors in over 240 shades ranging from classic to contemporary. Nail Abnormalities Clues to Systemic Disease. Silver poisoning will turn the nail itself a blue-gray color. Excessive fluoride ingestion can turn nails brown or black. Nail abnormalities are common, affecting the shape, thickness, or color of the nails. In this article, we look at possible abnormalities that affect the fingernails or toenails, with a picture.