It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Chloroquine in early pregnancy Which of the following statements concerning chloroquine is correct Hydroxychloroquine is predicted to increase the risk of haematological toxicity when given with penicillamine. Manufacturer advises avoid. Severity of interaction Severe Evidence for interaction Theoretical. Rabies vaccine. Hydroxychloroquine is predicted to decrease efficacy rabies vaccine. Manufacturer makes no recommendation. The study is based on warfarin sodium and hydroxychloroquine sulfate the active ingredients of Warfarin sodium and Plaquenil, respectively, and Warfarin sodium and Plaquenil the brand names. Other drugs that have the same active ingredients e.g. generic drugs are not considered. Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America. The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. Hydroxychloroquine interference with warfarin Plaquenil - Uses, Side Effects, Interactions., Warfarin sodium and Plaquenil drug interactions - from FDA. Plaquenil drug interactions side effectsPictures of plaquenil rashChloroquine methodPlaquenil westport ct visual field A more recent case series reported a corticosteroid interaction in 2 patients on warfarin therapy. The first patient, who received methylprednisolone 960 mg orally for 5 days, developed a nosebleed 5 days following completion of the steroid regimen. Effect of Oral Corticosteroids on Chronic Warfarin Therapy. Hydroxychloroquine - Side Effects, Dosage, Interactions.. Hydroxychloroquine Oral Interactions with Other Medication. Hydroxychloroquine oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or. Find patient medical information for Hydroxychloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Cigarette smoking has been suspected to increase the risk and the activity of systemic lupus erythematosus SLE 1,2 and cutaneous lupus. 3,4 Some data indicate that cigarette smoking might interfere with the effectiveness of hydroxychloroquine and chloroquine in cutaneous lupus. 3,4 As these antimalarial agents are partly metabolised via the cytochrome P450 enzyme system and as the constituents of cigarette smoke are known potent inducers of cytochrome P450, it has been hypothesised that.