But you may also be in the grip of a less tangible symptom: chronic fatigue. In fact, fatigue is one of the most common and frustrating RA symptoms.“RA fatigue is a symptom that we rheumatologists really struggle with understanding well," says Yousaf Ali, MBBS, a professor of medicine at the Icahn School of Medicine and chief of the division of rheumatology at Mount Sinai West Hospital in New York City. Reticulocytes chloroquine Aralen hydrochloride I started on the Plaquenil a little over a week ago. Not much in the way of side effects. Some minor stomach stuff but that could be normal and not related to the Plaquenil. I started at 200mg and increased to 400mg after a week. Andie213, my fatigue has been frustrating for me as well. Chronic fatigue syndrome can occur at any age, but it most commonly affects people in their 40s and 50s. Sex. Women are diagnosed with chronic fatigue syndrome much more often than men, but it may be that women are simply more likely to report their symptoms to a doctor. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. It’s also worth noting that there are other potential causes of fatigue, outside of RA. "It is a systemic type of exhaustion, meaning it affects your whole system instead of just a certain body part."People who have RA often describe their fatigue as a deep tiredness or slowing down, akin to the feeling someone might have while recovering from the flu. Plaquenil and chronic fatigue Plaquenil for CFS. ProHealth Fibromyalgia, ME/CFS and., Chronic fatigue syndrome - Symptoms and causes - Mayo Clinic Plaquenil and cataractsWhy is the drug hydroxychloroquine Sep 12, 2012 Plaquenil will also help with rashes. It does take awhile to build up in your system before you notice any results Make sure you see an eye doctor for a base line eye exam. If you use plaquenil there is a chance of a serious side effect, retinal damage.is important to get regular eye exams while you are taking this med. Plaquenil and Fibromyalgia - Chronic Illness Community.. Hydroxychloroquine Plaquenil. Will you have Fatigue with Plaquenil - eHealthMe. Chronic fatigue occurs when symptoms of exhaustion or lack of energy last over 6 months. Chronic fatigue is a symptom of many chronic conditions, including rheumatoid arthritis, fibromyalgia, or lupus. Although the exact cause of chronic fatigue is unknown, certain factors can play a role, such as infection, hormone level changes, and stress. Chronic fatigue is a common RA symptom. Discover six ways you can better manage fatigue and find more energy to deal with rheumatoid arthritis. Chronic Fatigue From RA 6 Ways to Fight Back. Talk to your doctor about this, but my guess is that the Plaquenil is not doing anything to cause the pain, but rather that it is not doing enough to prevent it. It sounds like your RA has probably gotten a bit out of control, relative, to your current treatment, and Plaquenil is not a particularly potent drug when it comes to managing joint pain.