Now a paper published January 17 in the journal describes a new drug combination that has stabilized Rosendahl's disease and increased both the quantity and quality of her life: Adding the anti-malaria drug chloroquine to her treatment stopped an essential process that Rosendahl's cancer cells had been using to resist therapy, re-sensitizing her cancer to the targeted treatment that had previously stopped working. Along with Rosendahl, two other brain cancer patients were treated with the combination and both showed similar, dramatic improvement. Plaquenil and motrin What does plaquenil do for autoimmune diseases Nurse teaching to a patient taking hydroxychloroquine Oct 27, 2016 Glioblastoma multiforme GBM is the most aggressive brain tumor. Despite its high degree of hypoxia, it can survive and resist anticancer treatments. Thus, it is important to study the main GBM adaptive strategies. Autophagy is a catabolic process that can be induced by hypoxia. The common dosing of 250 mg chloroquine phosphate daily contains about 150 mg chloroquine the remaining weight is the phosphate component. The names chloroquine and chloroquine phosphate are used interchangeably for practical purposes. Chloroquine has a long half-life in the body, so the daily timing might not be all that important. The long term metronomic dose of chloroquine when used for rheumatoid arthritis is the same as used in the brain tumor trials 250 mg chloroquine phosphate ~150 mg chloroquine base. You might be able to get away with combining it with cimetidine which has the effect of increasing plasma levels by inhibiting its metabolism to desethylchloroquine, but in that case regular eye exams may be even more important. They tested it for cancer and it came back positive," Lisa says. "When I was 21 they found a large mass in my brain and I had it resected right away. Chloroquine brain tumor Glioblastoma, hypoxia and autophagy a survival-prone., Our brain tumor cocktails and stories Questions on. Big blood clots during period with plaquenilPlaquenil ukEffect of chloroquine on sleChloroquine contraindicated pregnancy This medicine may add to the chance of getting some types of cancer. Talk with the doctor. Keep away from children. Accidental exposure may cause death. If a child takes chloroquine by accident, get medical help right away. If you are 65 or older, use chloroquine with care. You could have more side effects. Chloroquine Indications, Side Effects, Warnings -. Our brain tumor cocktails and stories Inhibitors of autophagy. Frontiers Re-purposing Chloroquine for Glioblastoma.. Vascular protection by chloroquine during brain tumor therapy with Tf- CRM107. Tf-CRM107 is a conjugate of transferrin and a point mutant of diphtheria toxin that selectively kills cells expressing high levels of the transferrin receptor. Tf-CRM107 has been infused intratumorally into patients with malignant brain tumors. Because chloroquine has already earned FDA approval as a safe and effective and inexpensive treatment for malaria, the paper points out that it should be possible to “quickly test” the effectiveness of adding autophagy inhibition to a larger sample of BRAF+ glioblastoma and other brain tumor patients. In a small number of patients with brain tumors, the team found that adding the autophagy inhibitor chloroquine after failure of the BRAFV600E inhibitor vemurafenib, it is possible to overcome kinase inhibitor resistance. The investigators have demonstrated.