Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Side effects of starting plaquenil Hydroxychloroquine drug class Malaria Mode of action of chloroquine and mechanism of chloroquine resistance Article PDF Available in Journal de Pharmacie Clinique 323143-153 September 2013 with 415 Reads Chloroquine is a 9-aminoquinoline that has been known since 1934. Specifically synthesised to be used as an antimalarial agent, chloroquine was subsequently shown to have immunomodulatory properties that have encouraged its application in the treatment of autoimmune diseases such as rheumatoid arthritis. Antimalarial drugs Mode of action and status of resistance. mechanism of action and resistance. general antimicrobial mecha nism of action of chloroquine. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine mechanism of action pdf Chloroquine - FDA prescribing information, side effects and uses, Effects of chloroquine on viral infections an old drug. Synthesis of chloroquine phosphateChloroquine resistant malaria drug of choicePlaquenil toxicity first screenin Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain. Chloroquine - FDA prescribing information, side effects.. PDF Antimalarial drugs Mode of action and status of.. Chloroquine in Cancer Therapy A Double-Edged Sword of.. Chloroquine- resistant parasites accumulate less chloroquine in the food vacuole than do sensitive parasites Fitch, 1970 and one assumption is that chloroquine resistance is not based on the mode of action of the drug but on the access of the drug to the parasite food vacuole. The mechanisms of action of hydroxychloroquine and chloroquine remain under continuous study in modern molecular medicine 17,18 using advanced tools in computational biology 19, synthetic biology. It is a prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses. PubChemThe mechanism of plasmodicidal action of chloroquine is not completely certain.