Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Normal dosage daily for plaquenil Plaquenil cause fatigue Plaquenil for lupus reviews fatigue Mechanism of action Hydroxychloroquine is weakly basic, which permits its uptake and concentration in a nonionised form within cells. Having entered the lysosomes inside the cell, the acidic environment traps and concentrates the drug in its ionised state. Definition NCI A 4-aminoquinoline with immunosuppressive, antiautophagy, and antimalarial activities. Although the precise mechanism of action is unknown, hydroxychloroquine may suppress immune function by interfering with the processing and presentation of antigens and the production of cytokines. Hydroxychloroquine is a 4-aminoquinoline with immunosuppressive, antiautophagy, and antimalarial activities. Although the precise mechanism of action is unknown, hydroxychloroquine may suppress immune function by interfering with the processing and presentation of antigens and the production of cytokines. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Hydroxychloroquine sulphate mechanism of action Hydroxychloroquine Plaquenil -, Hydroxychloroquine Chloroquine eye damageDoes hydroxychloroquine cause proteinuriaPlaquenil maculopathy reportPlaquenil and extreme fatiguePlaquenil cause dizziness after 2 years Hydroxychloroquine Sulfate is a synthetic derivative of quinolyl with chemotherapeutic and antibiotic properties, Hydroxychloroquine Sulfate acts against erythrocytic malarial parasites Plasmodium vivax, ovale, and malariae by concentrating in food vacuoles. It inhibits plasmodial heme polymerase and acts through other unknown mechanisms. Hydroxychloroquine sulfate C18H28ClN3O5S - PubChem. Hydroxychloroquine C18H26ClN3O - PubChem. Hydroxychloroquine - DrugBank. Hydroxychloroquine is classified as an anti-malarial drug. It is similar to chloroquine Aralen and is useful in treating several forms of malaria as well as lupus erythematosus and rheumatoid arthritis. Its mechanism of action is unknown. Hydroxychloroquine sulfate is a synthetic antimalarial drug which can also inhibit Toll-like receptor 7/9 TLR7/9 signaling. - Mechanism of Action & Protocol. Microbiology –Malaria. Mechanism of action The precise mechanism by which hydroxychloroquine exhibits activity against Plasmodium is not known. Hydroxychloroquine, like chloroquine, is a weak base and may exert its effect by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme.