Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Chloroquine dose for prophylaxis Can plaquenil cause headaches Hydroxychloroquine HCQ, a lysosomotropic amine, is an immunosuppressive agent presently being evaluated in bone marrow transplant patients to treat graft-versus-host disease. While its immunosuppressive properties have been attributed primarily to its ability to interfere with antigen processing, recent reports demonstrate HCQ also blocks T-cell activation in vitro. Hydroxychloroquine Plaquenil Is an Immunosuppressant. In my opinion, Plaquenil is best considered an immunosuppressant. It’s true that it’s different than other immunosuppressants like methotrexate or cyclosporine. It does not seem to predispose to cancer development but does predispose to some infections. Two studies have shown that shingles herpes zoster is increased in hydroxychloroquine users. Aug 02, 2010 Even while taking 400mg of Plaquenil and 15mg of Prednisone also an immunosuppressant, my immune system was still overactive. My Absolute Neutrophils good indicator of immune system function didn't get suppressed to a NORMAL range until I increased the Plaquenil to 600mg/day while still taking the Prednisone. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Hydroxychloroquine immunosuppressant Hydroxychloroquine - Wikipedia, Is Hydroxychloroquine Plaquenil an Immunosuppressant. Does plaquenil cause weight gain or loss Hydroxychloroquine Plaquenil, chloroquine Aralen, and quinacrine Atabrine are medications that were originally used to prevent or treat malaria. However, during World War II it was also found that these medications were effective in treating the symptoms of lupus. Treating Lupus with Anti-Malarial Drugs Johns Hopkins.. Do either hydroxychol/Plaquenil put you at risk for greater.. Hydroxychloroquine and the immune system Hi everyone.. Hydroxychloroquine and the immune system. It is listed as having a mild immunosuppressant effect in my book on RA, but one of the reasons for the blood tests is. Plaquenil Hydroxychloroquine is used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus & others. Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. It does not work against certain types of malaria chloroquine-resistant. The United States Center for.