If a patient is overweight, one should use the ideal body weight to assess whether the doaily dose is in the toxic range (/= 6.5 mg/kg/day). This graph shows various formulas that have been proposed for deriving ideal body weight for women, because virtually all cases of hydroxychloroquine toxicity have been female. Plaquenil for depression Hydroxychloroquine drug guide The most recent 2016 guidelines from the American Academy of Ophthalmology AAO recommend the dose of HCQ ≤5 mg/kg real body weight to minimize toxicity 1. According to these new guidelines, the risk of HCQ retinal toxicity is less than 1 % in the first year of therapy and less than 2 % up to 10 years of therapy. Nov 25, 2019 Alternate dosing based on body weight A total dose representing 25 mg/kg is administered in 3 days, as follows First dose 10 mg base/kg not to exceed 620 mg base orally Second dose 5 mg base/kg not to exceed 310 mg base orally 6 hours after first dose Third dose 5 mg base/kg orally 18 hours after second dose Why Use. Use in an outpatient setting for adult patients taking hydroxychloroquine Plaquenil. The current American Academy of Ophthalmology AAO guidelines, published in 2016, recommend a maximum daily hydroxychloroquine dose of ≤5.0 mg/kg of real weight. For this dosage, any woman with an ideal body weight less than 135 pounds would be in the toxic dose range. The usual hydroxychloroquine dose that is prescribed is 400 mg/day. Plaquenil dose based on weight Hydroxychloroquine Blood Levels in SLE Clarifying dosing., Hydroxychloroquine Dosage Guide with Precautions - Hydroxychloroquine used for hair lossChloroquine storage in retinaPlaquenil side effects skin discolorationPlaquenil dosage maculopathyChloroquine one drug treatment For children and infants, the dose is based on weight. Usually, 5 mg per kg of body weight about 2.3 mg per pound once weekly is recommended, not to exceed the normal adult dosage. Plaquenil comes only in adult-strength tablets, which taste extremely bitter when crushed or chewed. Plaquenil Dosage - eMedTV Health Information Brought To Life. Hydroxychloroquine Plaquenil Dosing Calculator - MDCalc. Hydroxychloroquine Side Effects, Dosage, Uses, and More. SAN FRANCISCO – Hydroxychloroquine Plaquenil dosing based on actual body weight – instead of ideal weight – is appropriate for patients with systemic lupus erythematosus SLE, according to a review of 686 lupus patients at Johns Hopkins University in Baltimore. Most were dosed by actual weight, 6.5 mg/kg up to a maximum of 400 mg/day. Jan 03, 2020 Weight based dosage in adults and pediatric patients 13 mg/kg 10 mg/kg base, not to exceed 800 mg 620 mg base followed by 6.5 mg/kg 5 mg/kg base, not to exceed 400 mg 310 mg base, at 6 hours, 24 hours and 48 hours after the initial dose. PLAQUENIL film-coated tablets cannot be divided, therefore they should not be used to treat patients who weigh less than 31 kg. Any concerns regarding dosage should be discussed with the prescribing physician. Discussion. A risk factor for Plaquenil hydroxychloroquine retinotoxicity is a daily dose that exceeds 5.0 mg of drug per kg of body weight. The tool on the right simply calculates this threshold based on a ppatient’s real body weight.