Canine uveodermatologic syndrome (Vogt-Koyanagi-Harada-like syndrome) is a syndrome of concurrent granulomatous uveitis and depigmenting dermatitis reported most commonly in the Akita, Samoyed, and Siberian husky. The cause of the disease unknown but in man a cell-mediated hypersensitivity to melanin and melanocytes in conjunction with the production of antibodies against melanin, gangliosides, and photoreceptors has been shown. Melanocytes in the uveal tract, inner ear, leptomeninges and skin are all affected. The syndrome is characterized by an acute onset of uveitis. Subsequent symmetrical depigmentation of the nose, lips, eyelids, and other pigmented areas begins within 10 days to several months. Histopathologic changes consist of a histiocytic interface dermatitis. Aggressive management of the uveitis is necessary to prevent posterior synechia, secondary glaucoma, cataracts, and loss of vision. 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